The following transit options are available in Mebane:
- The GoTriangle Orange-Durham Connector (ODX) bus that travels from Mebane to Hillsborough, Durham, and Chapel Hill.
- The Piedmont Authority for Regional Transportation (PART) Route 4 bus that travels from Greensboro to Mebane and Chapel Hill. Both bus routes stop at the Mebane Area Regional Hospital; the ODX bus also stops at Mebane City Hall and Richland Road in Efland.
- The Orange County Public Transit program offers a bus for those needing service during non-peak, mid-day hours, connecting Mebane and Efland to Hillsborough via US-70 and I-40. In Hillsborough, other transit options are available to further connect riders to Chapel Hill, Durham, and other Triangle destinations. Fares are $2 and free for seniors and small children.
- The Alamance County Transportation Authority (ACTA) offers rides at request throughout Alamance County between the hours of 5 a.m.; and 5:30 p.m. Rides must be scheduled by phone at 336-222-0565.